Diabetic Retinopathy (DR) affects individuals with long-term diabetes. Without early diagnosis, DR can lead to vision loss. Fundus photography captures the structure of the retina along with abnormalities indicative of the stage of the disease. Artificial Intelligence (AI) can support clinicians in identifying these lesions, reducing manual workload, but models require high-quality annotated datasets. Due to the complexity of retinal structures, errors in image acquisition and lesion interpretation of manual annotators can occur. We proposed a quality-control framework, ensuring only high-standard data is used for evaluation and AI training. First, an explainable feature-based classifier is used to filter inadequate images. The features are extracted both using image processing and contrastive learning. Then, the images are enhanced and put subject to annotation, using deep-learning-based assistance. Lastly, the agreement between annotators calculated using derived formulas determines the usability of the annotations.

Automatic diacritic restoration is crucial for text processing in languages with rich diacritical marks, such as Romanian. This study evaluates the performance of several large language models (LLMs) in restoring diacritics in Romanian texts. Using a comprehensive corpus, we tested models including OpenAI's GPT-3.5, GPT-4, GPT-4o, Google's Gemini 1.0 Pro, Meta's Llama 2 and Llama 3, MistralAI's Mixtral 8x7B Instruct, airoboros 70B, and OpenLLM-Ro's RoLlama 2 7B, under multiple prompt templates ranging from zero-shot to complex multi-shot instructions. Results show that models such as GPT-4o achieve high diacritic restoration accuracy, consistently surpassing a neutral echo baseline, while others, including Meta's Llama family, exhibit wider variability. These findings highlight the impact of model architecture, training data, and prompt design on diacritic restoration performance and outline promising directions for improving NLP tools for diacritic-rich languages.

The growing popularity of group activities increased the need to develop methods for providing recommendations to a group of users based on the collective preferences of the group members. Several group recommender systems have been proposed, but these methods often struggle due to sparsity and high-dimensionality of the available data, common in many real-world applications. In this paper, we propose a group recommender system called Group Soft-Impute SVD, which leverages soft-impute singular value decomposition to enhance group recommendations. This approach addresses the challenge of sparse high-dimensional data using low-rank matrix completion. We compared the performance of Group Soft-Impute SVD with Group MF based approaches and found that our method outperforms the baselines in recall for small user groups while achieving comparable results across all group sizes when tasked on Goodbooks, Movielens, and Synthetic datasets. Furthermore, our method recovers lower matrix ranks than the baselines, demonstrating its effectiveness in handling high-dimensional data.

Efficient routing of mobile robot fleets is crucial in intralogistics, where delays and deadlocks can substantially reduce system throughput. Roadmap design, specifying feasible transport routes, directly affects fleet coordination and computational performance. Existing approaches are either grid-based, compromising geometric precision, or continuous-space approaches that disregard practical constraints. This paper presents an automated roadmap generation approach that bridges this gap by operating in continuous-space, integrating station-to-station transport demand and enforcing minimum distance constraints for nodes and edges. By combining free space discretization, transport demand-driven $K$-shortest-path optimization, and path smoothing, the approach produces roadmaps tailored to intralogistics applications. Evaluation across multiple intralogistics use cases demonstrates that the proposed approach consistently outperforms established baselines (4-connected grid, 8-connected grid, and random sampling), achieving lower structural complexity, higher redundancy, and near-optimal path lengths, enabling efficient and robust routing of mobile robot fleets.

--Audio denoising is critical in signal processing, enhancing intelligibility and fidelity for applications like restoring musical recordings. This paper presents a proof -of-concept for adapting a state -of -the -art neural audio codec, the Descript Audio Codec (DAC), for music denoising. This work overcomes the limitations of traditional architectures like U - Nets by training the model on a large-scale, custom -synthesized dataset built from diverse sources. Training is guided by a multi-objective loss function that combines time-domain, spectral, and signal -level fidelity metrics. Ultimately, this paper aims to present a PoC for high -fidelity, generative audio restoration. Noise reduction is a fundamental part of audio signal processing, substantially improving signal quality and intelligibility across domains like speech processing [1-3], music production and restoration [1], and bioacoustics analysis [2].

Artificial intelligence (AI) agents are emerging as transformative tools in drug discovery, with the ability to autonomously reason, act, and learn through complicated research workflows. Building on large language models (LLMs) coupled with perception, computation, action, and memory tools, these agentic AI systems could integrate diverse biomedical data, execute tasks, carry out experiments via robotic platforms, and iteratively refine hypotheses in closed loops. We provide a conceptual and technical overview of agentic AI architectures, ranging from ReAct and Reflection to Supervisor and Swarm systems, and illustrate their applications across key stages of drug discovery, including literature synthesis, toxicity prediction, automated protocol generation, small-molecule synthesis, drug repurposing, and end-to-end decision-making. To our knowledge, this represents the first comprehensive work to present real-world implementations and quantifiable impacts of agentic AI systems deployed in operational drug discovery settings. Early implementations demonstrate substantial gains in speed, reproducibility, and scalability, compressing workflows that once took months into hours while maintaining scientific traceability. We discuss the current challenges related to data heterogeneity, system reliability, privacy, and benchmarking, and outline future directions towards technology in support of science and translation.

We propose Collab-REC, a multi-agent framework designed to counteract popularity bias and enhance diversity in tourism recommendations. In our setting, three LLM-based agents -- Personalization, Popularity, and Sustainability generate city suggestions from complementary perspectives. A non-LLM moderator then merges and refines these proposals via multi-round negotiation, ensuring each agent's viewpoint is incorporated while penalizing spurious or repeated responses. Experiments on European city queries show that Collab-REC improves diversity and overall relevance compared to a single-agent baseline, surfacing lesser-visited locales that often remain overlooked. This balanced, context-aware approach addresses over-tourism and better aligns with constraints provided by the user, highlighting the promise of multi-stakeholder collaboration in LLM-driven recommender systems.

The task here is to predict the toxicological activity of chemical compounds based on the Tox21 dataset, a benchmark in computational toxicology. After a domain-specific overview of chemical toxicity, we discuss current computational strategies, focusing on machine learning and deep learning. Several architectures are compared in terms of performance, robustness, and interpretability. This research introduces a novel image-based pipeline based on DenseNet121, which processes 2D graphical representations of chemical structures. Additionally, we employ Grad-CAM visualizations, an explainable AI technique, to interpret the model's predictions and highlight molecular regions contributing to toxicity classification. The proposed architecture achieves competitive results compared to traditional models, demonstrating the potential of deep convolutional networks in cheminformatics. Our findings emphasize the value of combining image-based representations with explainable AI methods to improve both predictive accuracy and model transparency in toxicology.

In recent years, large language models (LLMs) have demonstrated significant potential across various natural language processing (NLP) tasks. However, their performance in domain-specific applications and non-English languages remains less explored. This study introduces a novel Romanian-language dataset for multiple-choice biology questions, carefully curated to assess LLM comprehension and reasoning capabilities in scientific contexts. Containing approximately 14,000 questions, the dataset provides a comprehensive resource for evaluating and improving LLM performance in biology. We benchmark several popular LLMs, analyzing their accuracy, reasoning patterns, and ability to understand domain-specific terminology and linguistic nuances. Additionally, we perform comprehensive experiments to evaluate the impact of prompt engineering, fine-tuning, and other optimization techniques on model performance. Our findings highlight both the strengths and limitations of current LLMs in handling specialized knowledge tasks in low-resource languages, offering valuable insights for future research and development.

Although paralinguistic cues are often considered the primary drivers of speech emotion recognition (SER), we investigate the role of lexical content extracted from speech and show that it can achieve competitive and in some cases higher performance compared to acoustic models. On the MELD dataset, our lexical-based approach obtains a weighted F1-score (WF1) of 51.5%, compared to 49.3% for an acoustic-only pipeline with a larger parameter count. Furthermore, we analyze different self-supervised (SSL) speech and text representations, conduct a layer-wise study of transformer-based encoders, and evaluate the effect of audio denoising.